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    Fast facts on DMT

    Here are some key points about DMT. More detail and supporting information is in the main article.

    • DMT has been used as a drug for thousands of years.
    • Use of the drug as part of shamanic ritual is common in South America.
    • Side effects include powerful hallucinations.
    • Due to the nature of the drug, DMT is known as the “spirit molecule.

    It is typically consumed in the following ways:

    • vaporized or smoked in a pipe
    • consumed orally in brews like ayahuasca
    • snorted or injected on rare occasions

    The chemical root structure of DMT is similar to the anti-migraine drug sumatriptan, and it acts as a non-selective agonist at most or all of the serotonin receptors, particularly at the serotonin 5-ht2a receptor. Serotonin is a neurotransmitter that has a large effect on the majority of our brain cells.

    There is some evidence that DMT is also produced endogenously, in other words, it is produced naturally in the body, specifically in the pineal gland in the brain.

    When smoked, the average dose of DMT is believed to be somewhere between 30 to 150 milligrams (mg), and the onset of action can be felt almost instantly. The effects peak and plateau for 3 to 5 minutes, and gradually drop off with the duration of effect totaling 30 to 45 minutes.

    When consumed as a brew, the dose is between 35 to 75 mg. Effects begin after 30 to 45 minutes, peak after 2 to 3 hours and are resolved in 4 to 6 hours.

    DMT street names

    DMT is referred to by a number of slang terms:

    • dimitri
    • businessman’s trip
    • businessman’s special
    • fantasia
    • forty-five-minute psychosis
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